Unraveling the Progression of Ischemic Core Genome-Wide by Bioinformatics Analysis of Permanent Middle Cerebral Artery Occlusion (PMCAO) Mouse Model Brain Regions Genes

Motohide Hori, Tomoya Nakam

Abstract

The neuropeptide, pituitary adenylate-cyclase activating polypeptide (PACAP) , is the major focus of research as a neuroprotective factor in the group of Prof. S. Shioda. A major emphasis of the research is on the neuroprotective effects of PACAP38 on the brain, particularly in brain ischemia . Therein, a permanent middle cerebral artery occlusion (hereafter referred to as PMCAO) mouse model has been established and used for unraveling of the genome-wide gene expression profiles by high-throughput omics approach, namely DNA microarray technology.