Use of D2-40 as an IHC marker is inappropriate for 3D Reconstruction of the Venous System

Short Communication

Noriko KUROBE

Abstract

The circulatory system plays an important role in performing life activities, but the mechanisms of embryologic distribution have not been understood clearly. This study aimed to elucidate the venous vasculature in human fetuses with 3D Reconstruction of vessel and nerve localisation. According to this article, D2-40 was used as a venous marker, whereas we used αSMA instead of D2-40. D2-40: Podoplanin (PDPN) a lymphatic and mesotheliomal marker, is not expressed in normal blood vessels. The aim of this paper is to report embryological evidence disputing the detectability of blood vessels using D2-40 and provide the correct blood vessel specific markers that should be chosen instead. Unfortunately, the research was not the first good report about the vessel-system of human fetus. This is the article which was submitted by one of co-authors without the approval of Kurobe.

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