Vitamin d supplementation explodes the triangle of danger \"iron deficiency anemia, inflammation and hypovitaminosis D in pediatric patients on hemodialysis

Soha Abdelhady Ibrahim, Eman R

Abstract

Vitamin D deficiency is extremely frequent in chronic kidney disease (CKD) and is associated with erythropoietin hypo-responsiveness. Hepcidin, the primary regulator of iron homeostasis, may play a critical role in the response of patients with anem ia to iron and erythropoiesis-stimulating agent therapy; however, the participation of hepcidin to anemia in hemodialysis (HD) patients had not been completely characterized. To evaluate the relationship between serum hepcidin, indicators of anemia, iron status, inflammation and 25-hydroxy vitamin D (25-OH D) leve ls in children with CKD on HD and the impact of vitamin D therapy on these parameters.